GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs1577917 | 1 | rs34106666 | chr6:86676258 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.89 | 5.95E-10 | Response to antipsychotic treatment |
| THYM | cis | rs2243480 | 1 | rs34136756 | chr7:65381256 | CCT6P1 | chr7:65216092-65228661:+ | 0.68 | 4.97 | 3.0E-6 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs34192067 | chr7:65887657 | CCT6P1 | chr7:65216092-65228661:+ | 0.59 | 4.86 | 4.58E-6 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs34193460 | chr7:65393110 | CCT6P1 | chr7:65216092-65228661:+ | 0.7 | 5.13 | 1.51E-6 | Diabetic kidney disease |
| THYM | cis | rs1577917 | 1 | rs34281561 | chr6:86701872 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.89 | 5.95E-10 | Response to antipsychotic treatment |
| THYM | cis | rs911119 | 1 | rs34374560 | chr20:23609462 | CST9 | chr20:23583049-23586610:- | -0.51 | -4.73 | 7.71E-6 | Chronic kidney disease |
| THYM | cis | rs344081 | 1 | rs344081 | chr3:156555984 | LEKR1 | chr3:156544076-156763918:+ | -0.72 | -4.3 | 4.1E-5 | Bone mineral density |
| THYM | cis | rs344081 | 1 | rs344088 | chr3:156561361 | LEKR1 | chr3:156544076-156763918:+ | -0.72 | -4.3 | 4.1E-5 | Bone mineral density |
| THYM | cis | rs344081 | 1 | rs344090 | chr3:156563140 | LEKR1 | chr3:156544076-156763918:+ | -0.72 | -4.3 | 4.1E-5 | Bone mineral density |
| THYM | cis | rs12780845 | 1 | rs34434809 | chr10:17187634 | CUBN | chr10:16865966-17171816:- | 0.32 | 4.95 | 3.16E-6 | Homocysteine levels |
| THYM | cis | rs12780845 | 1 | rs34500464 | chr10:17191996 | CUBN | chr10:16865966-17171816:- | 0.3 | 4.68 | 9.61E-6 | Homocysteine levels |
| THYM | cis | rs2243480 | 1 | rs34529418 | chr7:65403209 | CCT6P1 | chr7:65216092-65228661:+ | 0.67 | 4.9 | 3.88E-6 | Diabetic kidney disease |
| THYM | cis | rs2564921 | 1 | rs34530577 | chr3:53103796 | RFT1 | chr3:53122503-53164470:- | -0.44 | -4.96 | 3.05E-6 | Height |
| THYM | cis | rs9976767 | 1 | rs34544259 | chr21:43834854 | TMPRSS3 | chr21:43791996-43816200:- | 0.5 | 4.75 | 7.26E-6 | Type 1 diabetes |
| THYM | cis | rs12780845 | 1 | rs34558323 | chr10:17184228 | CUBN | chr10:16865966-17171816:- | 0.3 | 4.6 | 1.29E-5 | Homocysteine levels |